Initially, Semax drug was developed in Russia to treat and prevent the circulatory disorders including strokes and brain damage. This is an experimental drug. It has also been identified as a “nootropic” or “cognitive enhancer.” Semax has also shown effects on animal models like it helps reducing stress and has also helped in enhancing memory performance.
Formulation of Semax
Semax, s synthetic peptide structure is based on the molecular structure of adrenocorticotropic hormone (ACTH). So, Semax is the analog of ACTH which has long lasting actions and it is also known as the Heptapeptide SEMAX (MEHFPGP). Additionally, Semax has also shown prolonged neuropathic activity.
Initially, Semax was used on the patients who used to experience pathologies connected to brain circulation dysfunction. Semax has effects on carboxypeptidase which might increase physical performance and adaptation capacities in exposure due to high intensity and exercises at high doses, and that’s why Semax has also been suggested in literature.
Research and study on Semax
There has been several research performed to understand effects and side effects of this drug. One such research was carried out to understand the effects of Semax on the learning ability and pain and sensitivity in the white rats. The rats were given different doses via the intranasal and intraperitoneal routes. It was concluded that Semax had nootropic effects and analgesic actions. The intranasal Semax was seen more effective in improving the ability to learn in animals. However, it didn’t show any affects on pain sensitivity.
The results proved that in mediating nootropic and the analgesic effects of Semax, different mechanisms and brain structures are involved.
Working of Semax
As we know that Pituitary gland which is situated in human brain secretes various hormones. Likewise, an hormone named adrenocorticotropic is secreted by the pituitary gland which stimulates the release of cortisol coming from the adrenal gland. It maintains blood pressure and regulates glucose metabolism.
Likewise, the Semax nasal spray delivers the synthetic form of this hormone to the patient’s body. Even after being a synthetic hormone, its working is exactly like a regular human hormone, and it helps to counteract stress brought by external factors from the environment.
Semax also optimizes the brain activity that helps to reduce certain behaviors like procrastination and avoidance. Semax also induces a controlled state of mental stress, which eventually optimizes the brain function. Semax works on different parts of brain including limbic reticular complex, hippocampus and body’s systems and receptors through chemical stimulation.
Semax is often prescribed for Anti-thrombosis, ADHD, Learning, Gastric protection, Physical exertion, improvement of pain and metal toxicities.
Prescribed dosage of Semax
Semax’s 1mg/ml subcutaneous injection is provided in a 5mL vial. It is suggested to Inject 0.3-1 mL subcutaneously twice in a week depending on the patient’s response.
It is to be noted that different countries and even doctors use Semax to treat varied health conditions. Semax anxiety is applied intranasally, although the drops differ according to the treatment and the patient’s health condition. Injectable semax is also available but it could be administered only by health professionals.
Considering its effects, the drug should only be taken on the prescription of a health professional. It is better to consult with a doctor before taking Semax if the doctor has already recommended some other medicines.
Uses of Semax
- Treatment of ADHD
Semax has shown its benefits against the treatment of ADHD.As per the studies and research, Semax is proven to improve memory and increase neurotransmitters that are lower in patients with ADHD.
Semax is used as a common alternative for drug therapy for children with ADHD in Russia. With Semax addresses, ADHD could disturb levels of dopamine as ADHD is possibly a neurodevelopmental condition.
- Oxidative Damage
Originally, Semax was invented for heart attack or stroke victims. It helps in preventing oxidative degeneration. As per researchers, this is because of the effect of Semax on oxidative protection.
Due to oxidative stress, oxidative damage happens. Oxidative stress is a condition in the human body in which an imbalance of antioxidants and free radicals happens. However, mild oxidative stress which is caused by physical exercise is proven to be beneficial in regulating human body’s tissue growth since it stimulates antioxidant production. But contrary to it, long-term oxidative stress, resulted from any diseases or conditions like a stroke can somehow damage patient’s protein cells as well as DNA.
- Treating Stress
In today’s fast world, the lives of everyone have become so fast and tedious that no one gives enough time to their mental health and eventually everyday challenges start causing stress to a person.
There are many reasons which are causing stress. Some of them are lack of sleep, sickness, and physical injury.
Accordingly, because of stress, the body might respond negatively in different ways, like, by increasing liver enzymes production. Semax proves itself quite useful in such situation as it prevents enzyme production caused by stress.
- Improvement in Blood Circulation
Stroke’s major risk factor is experiencing weak blood circulation to the brain. This condition is called as cerebrovascular insufficiency. Patients in various stages of this condition have seen stabilized progression. Such patients, when treated with Semax, has shown decrease in the stroke risks as Semax shows effects in improving their blood circulation.
Sometimes, because of high blood pressure, a condition arises in which the heart enlarges, Semax has shown beneficial effects in such case as well. Adding to it, Semax also prevents the development of heart failure, followed by a heart attack.
- Relieving Pain
The Human brain releases enkephalins when the body feels pain. Enkephalins are the neurotransmitters which helps in lessening the sensation of pain. These neurotransmitters also help to change the pain perception by reducing the feelings of panic which generally occurs when human body feels pain.
In this case, Semax helps by preventing the breakdown of enkephalins in the body. Adding to it, Semax also increase the production of enkephalin which eventually helps in reducing the severity of pain.
- Improvement of Memory Retention
Usually, Neurotransmitters like enkephalins influences perception. Therefore, Semax can also help in increasing the formulation of memories. Even, Semax has also shown its results in the regulation of human moods.
Duration of effects of Semax
As per studies, Semax has no significant variation of duration times. However, intranasal Semax, when compared to the injections, lasts for a shorter time. The reported time gap should be between two to ten hours.
Conclusion
Overall, SEMAX has a variety of uses and benefits. Although, we recommend that you consult your doctor before you begin taking it to avoid any side effects and complications.
Overall, Semax has been proven a great drug and has a variety of uses and benefits in treating various health conditions. However, it is better to use it if prescribed from any doctor or health professional considering the complications or side effects it might cause.
